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Increased rates of deposition in the respiratory tract lead to increased rates of nicotine delivery to the brain, which intensify the addictive properties of a drug Henningfield et al. Sulfur-containing gases result from the combustion of sulfur-containing amino acids and proteins Horton and Guerin Collectively, results of these studies are consistent with the demonstrated clastogenicity chromosome-breaking ability of cigarette smoke and condensate and cigarette smoke in experimental systems and in humans. Nicotine is addictive in humans because a portion of the nicotine molecule is similar to acetylcholine, an important brain neurotransmitter Brody et al. Little is known about the temporal variability of DNA adducts within a target or surrogate tissue. Smokers prefer a cigarette on which they do not have to draw too hard because of changes in pressure drop as a result of design.
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